Within days of treatment, we detected a large number of low-frequency mutations in patients and that these new mutations could persist and, in some cases, were fixed in the virus population … This commonly used class of antivirals has the capability to supercharge SARS-CoV-2 evolution, and uncontrolled use may generate new variants with a transmission advantage that prolongs the pandemic and makes other therapeutics less effective.
https://www.medrxiv.org/content/10.1101/2022.12.21.22283811v1
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