SARS-CoV-2 spike ectodomain targets α7 nicotinic acetylcholine receptors

 

The SARS-CoV-2 glycoprotein contains a neurotoxin-like region that has sequence similarities to the rabies virus and the HIV glycoproteins, as well as to snake neurotoxins, which interact with nicotinic acetylcholine receptor (nAChR) subtypes via this region.

https://www.jbc.org/article/S0021-9258(23)01735-0/fulltext